发明公开
- 专利标题： THIAZOLE DERIVATIVE AS PROTEIN KINASE C INHIBITORS
- 专利标题（中）： 噻唑衍生物作为蛋白激酶C抑制剂
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申请号： EP97933046.0申请日： 1997-07-29
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公开(公告)号： EP0858452A1公开(公告)日： 1998-08-19
- 发明人: MORI, Toyoki , TOMINAGA, Michiaki , TABUSA, Fujio , NAGAMI, Kazuyoshi , ABE, Kaoru , NAKAYA, Kenji , TAKEMURA, Isao , SHINOHARA, Tomoichi , TANADA, Yoshihisa , YAMAUCHI, Takahito
- 申请人： OTSUKA PHARMACEUTICAL CO., LTD.
- 申请人地址： 9, Kanda-Tsukasacho 2-chome Chiyoda-ku Tokyo 101 JP
- 专利权人： OTSUKA PHARMACEUTICAL CO., LTD.
- 当前专利权人： OTSUKA PHARMACEUTICAL CO., LTD.
- 当前专利权人地址： 9, Kanda-Tsukasacho 2-chome Chiyoda-ku Tokyo 101 JP
- 代理机构： von Kreisler, Alek, Dipl.-Chem., et al
- 优先权： JP19960200898 19960731
- 国际公布： WO1998004536 19980205
- 主分类号： C07D277
- IPC分类号： C07D277 ; C07D317 ; C07D417 ; C07D471 ; C07D487
摘要：
A thiazole compound of formula (I), wherein T is lower alkylene; u is 0 or 1; R?1 and R2¿ are the same or different and are each H, or lower alkyl, etc.; R3 is (1) or (2); R4 is H or lower alkanoyloxy-lower alkyl, which shows inhibitory activity or protein kinase C(PKC, Ca2+/phospholipid-depending serine/threonine protein phosphatase), and are useful as a protein kinase C inhibitor.
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