发明公开
- 专利标题： DOPAMINE TRANSPORTER IMAGING AGENT
- 专利标题（中）： PICTURES令人信服物质多巴胺转运体
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申请号： EP96941959.0申请日： 1996-10-31
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公开(公告)号： EP0859641A1公开(公告)日： 1998-08-26
- 发明人: MELTZER, Peter, C. , MADRAS, Bertha, K. , DAVISON, Alan , BLUNDELL, Paul , MAHMOOD, Ashfaq , JONES, Alun, G.
- 申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , ORGANIX, INC. , Massachusetts Institute of Technology
- 申请人地址： University Place, 124 Mount Auburn Cambridge, Massachusetts 02138-5701 US
- 专利权人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE,ORGANIX, INC.,Massachusetts Institute of Technology
- 当前专利权人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE,ORGANIX, INC.,Massachusetts Institute of Technology
- 当前专利权人地址： University Place, 124 Mount Auburn Cambridge, Massachusetts 02138-5701 US
- 代理机构： Prüfer, Lutz H., Dipl.-Phys., et al
- 优先权： US19950552584 19951103
- 国际公布： WO1997016210 19970509
- 主分类号： A61K51
- IPC分类号： A61K51 ; C07C69 ; C07D451 ; C07F13
摘要：
Radiopharmaceutical compounds are disclosed. A tropane compound is linked through the N atom at the 8-position to a chelating ligand capable of complexing technetium or rhenium to produce a neutral labeled complex that selectively binds to the dopamine transporter. These compounds can be prepared as separate diastereoisomers as well as a mixture of diastereoisomers. Also disclosed are radiopharmaceutical kits for preparing the labeled radiopharmaceutical compounds.
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