发明公开
- 专利标题： TUMORVAKZINE UND VERFAHREN ZU IHRER HERSTELLUNG
- 专利标题（英）： Tumour vaccine and process for the preparation thereof
- 专利标题（中）： 肿瘤疫苗及其制备方法
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申请号： EP96939870.0申请日： 1996-11-21
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公开(公告)号： EP0866851A1公开(公告)日： 1998-09-30
- 发明人: SCHMIDT, Walter , BIRNSTIEL, Max , SCHWEIGHOFFER, Tamàs , STEINLEIN, Peter , BUSCHLE, Michael
- 申请人： Boehringer Ingelheim International GmbH
- 申请人地址： Postfach 200 55216 Ingelheim DE
- 专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人地址： Postfach 200 55216 Ingelheim DE
- 优先权： DE19951043649 19951123; DE19961007044 19960224
- 国际公布： WO1997019169 19970529
- 主分类号： C12N5
- IPC分类号： C12N5 ; A61K31 ; A61K35 ; A61K38 ; A61K39 ; A61K48 ; A61P35 ; C07K7 ; C07K14
摘要：
The invention relates to a tumour vaccine and a process for the preparation thereof. The tumour vaccine contains tumour cells, at least a portion of which has at least one MHC-I-haplotype of the patient on the cell surface, and which have been loaded in such a manner with one or a plurality of peptides bonding to the MHC-I-molecule that said tumour cells are recognised as foreign within the context of the peptides by the patient's immune system and trigger a cellular immune response. Loading takes place in the presence of a polycation such as polylysine.
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