发明公开
- 专利标题: COMPLEMENTARY ADENOVIRAL VECTOR SYSTEMS AND CELL LINES
- 专利标题(中): 互补ADENOVIRENVEKTORSYSTEME及细胞系
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申请号: EP96944346.0申请日: 1996-12-12
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公开(公告)号: EP0870049A2公开(公告)日: 1998-10-14
- 发明人: KOVESDI, Imre , BROUGH, Douglas, E. , MCVEY, Duncan, L. , BRUDER, Joseph, T. , LIZONOVA, Alena
- 申请人: GENVEC, INC.
- 申请人地址: 12111 Parklawn Drive Rockville, MD 20852 US
- 专利权人: GENVEC, INC.
- 当前专利权人: GENVEC, INC.
- 当前专利权人地址: 12111 Parklawn Drive Rockville, MD 20852 US
- 代理机构: Wössner, Gottfried, Dr. Dipl.-Chem.
- 优先权: US19950572126 19951214
- 国际公布: WO1997021826 19970619
- 主分类号: C12N15
- IPC分类号: C12N15 ; A61K31 ; A61K35 ; A61K48 ; A61P37 ; A61P43 ; C07K14 ; C12N5 ; C12N7 ; C12Q1 ; G01N33 ; A61K38 ; C12R1
摘要:
The present invention provides multiply replication deficient adenoviral vectors having a spacer in at least one replication deficient adenoviral region, as well as complementing cell lines therefor. Also provided are means of constructing the multiply replication deficient adenoviral vectors and methods of use thereof, e.g., in gene therapy.
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