发明授权
- 专利标题： TOXIC-PROTEIN EXPRESSING VIRUSES AND PRODUCER CELL LINES
- 专利标题（中）： 毒蛋白表达生产细胞病毒和
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申请号： EP96945414.9申请日： 1996-12-20
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公开(公告)号： EP0870050B1公开(公告)日： 2002-06-19
- 发明人: CHADA, Sunil , DePOLO, Nicholas, J. , SAUTER, Sybille , ROBBINS, Joan , JOLLY, Douglas, J. , MANNING, William, C. , MURPHY, John, E. , RALSTON, Robert, O., II
- 申请人： CHIRON CORPORATION
- 申请人地址： 4560 Horton Street Emeryville California 94608-2916 US
- 专利权人： CHIRON CORPORATION
- 当前专利权人： CHIRON CORPORATION
- 当前专利权人地址： 4560 Horton Street Emeryville California 94608-2916 US
- 代理机构： Goldin, Douglas Michael
- 优先权： US580556 19951229; US580554 19951229
- 国际公布： WO9724452 19970710
- 主分类号： C12N15/86
- IPC分类号： C12N15/86 ; C12N15/47 ; C12N7/01 ; C12N5/10
摘要：
Expression vectors are provided which have a tightly controllable promoter which directs the expression of a fusogenic protein. Also provided are nucleic acid molecules which encode toxic of fusogenic proteins, wherein one or more cysteine residues in the nucleic acid molecule has been altered to an opal termination codon.
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