发明授权
EP0871448B1 ARYL AND HETEROARYL QUINAZOLINE COMPOUNDS WHICH INHIBIT CSF-1R RECEPTOR TYROSINE KINASE
失效
抑制CSF-1R受体酪氨酸激酶的芳基和杂芳基喹唑啉化合物
- 专利标题： ARYL AND HETEROARYL QUINAZOLINE COMPOUNDS WHICH INHIBIT CSF-1R RECEPTOR TYROSINE KINASE
- 专利标题（中）： 抑制CSF-1R受体酪氨酸激酶的芳基和杂芳基喹唑啉化合物
-
申请号： EP95904308.4申请日： 1994-12-08
-
公开(公告)号： EP0871448B1公开(公告)日： 2005-03-02
- 发明人: MYERS, Michael, R. , SPADA, Alfred, P. , MAGUIRE, Martin, P. , PERSONS, Paul, E. , ZILBERSTEIN, Asher , HSU, Chin-Yi, Jenny , JOHNSON, Susan, E.
- 申请人： Aventis Pharmaceuticals Inc.
- 申请人地址： Route 202-206, P.O. Box 6800 Bridgewater, NJ 08807 US
- 专利权人： Aventis Pharmaceuticals Inc.
- 当前专利权人： Aventis Pharmaceuticals Inc.
- 当前专利权人地址： Route 202-206, P.O. Box 6800 Bridgewater, NJ 08807 US
- 代理机构： Hammond, Andrew David
- 优先权： US166199 19931210; US229886 19940419
- 国际公布： WO1995015758 19950615
- 主分类号： A61K31/505
- IPC分类号： A61K31/505 ; A61K31/535 ; A61P35/04 ; C07D239/72 ; C07D239/74 ; C07D239/88 ; C07D239/93 ; C07D239/94 ; C07D241/04 ; C07D265/28 ; C07D319/18 ; A61K31/00
摘要：
This invention relates to the modulation and/or inhibition of cell signaling, cell proliferation, cell inflammatory response, the control of abnormal cell growth and cell reproduction. More specifically, this invention relates to the use of mono- and/or bicyclic aryl or heteroaryl quinazoline compounds in inhibiting cell proliferation, including compounds which are useful protein tyrosine kinase (PTK) inhibitors. The method of treating cell proliferation and/or differentiation or mediator release using said quinazoline compounds and their use in pharmaceutical compositions is described.
信息查询
