发明公开
EP0882699A1 AMINO COMPOUNDS AND ANGIOTENSIN IV RECEPTOR AGONISTS
失效
AMINOVERBINDUNGEN UND ANGIOTENSIN IV REZEPTOR AGONISTEN
- 专利标题： AMINO COMPOUNDS AND ANGIOTENSIN IV RECEPTOR AGONISTS
- 专利标题（中）： AMINOVERBINDUNGEN UND ANGIOTENSIN IV REZEPTOR AGONISTEN
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申请号： EP97933908.2申请日： 1997-08-05
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公开(公告)号： EP0882699A1公开(公告)日： 1998-12-09
- 发明人: KOBORI, Takeo , GODA, Kenichi , SUGIMOTO, Kikuo , OTA, Tomomi, Taisho Pharmaceutical Co., Ltd. , TOMISAWA, Kazuyuki, Taisho Pharmaceutical Co. Ltd.
- 申请人： TAISHO PHARMACEUTICAL CO. LTD , SAGAMI CHEMICAL RESEARCH CENTER
- 申请人地址： 24-1 Takata 3-chome Toshima-ku Tokyo 171 JP
- 专利权人： TAISHO PHARMACEUTICAL CO. LTD,SAGAMI CHEMICAL RESEARCH CENTER
- 当前专利权人： TAISHO PHARMACEUTICAL CO. LTD,SAGAMI CHEMICAL RESEARCH CENTER
- 当前专利权人地址： 24-1 Takata 3-chome Toshima-ku Tokyo 171 JP
- 代理机构： Weisert, Annekäte, Dipl.-Ing. Dr.-Ing.
- 优先权： JP207010/96 19960806
- 国际公布： WO9805624 19980212
- 主分类号： C07C211/13
- IPC分类号： C07C211/13 ; C07C211/18 ; C07C211/22 ; C07C211/25 ; C07C211/27 ; C07C211/28 ; C07C215/52 ; C07K5/06 ; C07K5/08 ; A61K31/165 ; A61K31/24
摘要：
The present invention provides an amino compound represented by Formula:
wherein X is CH 2 NH or CONH, Y is CH 2 NH or CONH with the proviso that X and Y are not CONH at the same time; Z is CH=C(R 4 )R 5 , CH 2 CH(R 4 )R 5 or an alkoxycarbonyl group, R 1 is a hydrogen atom; a lower alkyl group, a cycloalkyl group, a cycloalkyl-substituted alkyl group, an aralkyl group or an aryl group, each group of which is substituted or unsubstituted, R 2 and R 3 are each independently a lower alkyl group or an aralkyl group, each group of which is substituted or unsubstituted, and R 4 and R 5 are each independently a hydrogen atom; an alkyl group, an aralkyl group, an aryl group or a heteroaryl group, each group of which is substituted or unsubstituted, or a pharmaceutically acceptable salt thereof; a medicine comprising the amino compound of Formula (1) or a pharmaceutically acceptable salt; and an angiotensin IV receptor agonist containing the same as an effective component, which are useful, in particular, as a therapeutical drug (antagonist or agonist) for various diseases in which angiotensin IV participates, for example, acceleration of renal blood flow, cerebral vasodilation, inhibition of cell proliferation and hypermnesia.
wherein X is CH 2 NH or CONH, Y is CH 2 NH or CONH with the proviso that X and Y are not CONH at the same time; Z is CH=C(R 4 )R 5 , CH 2 CH(R 4 )R 5 or an alkoxycarbonyl group, R 1 is a hydrogen atom; a lower alkyl group, a cycloalkyl group, a cycloalkyl-substituted alkyl group, an aralkyl group or an aryl group, each group of which is substituted or unsubstituted, R 2 and R 3 are each independently a lower alkyl group or an aralkyl group, each group of which is substituted or unsubstituted, and R 4 and R 5 are each independently a hydrogen atom; an alkyl group, an aralkyl group, an aryl group or a heteroaryl group, each group of which is substituted or unsubstituted, or a pharmaceutically acceptable salt thereof; a medicine comprising the amino compound of Formula (1) or a pharmaceutically acceptable salt; and an angiotensin IV receptor agonist containing the same as an effective component, which are useful, in particular, as a therapeutical drug (antagonist or agonist) for various diseases in which angiotensin IV participates, for example, acceleration of renal blood flow, cerebral vasodilation, inhibition of cell proliferation and hypermnesia.
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