发明公开
- 专利标题: CARTILAGE/BONE INDUCING MATERIALS FOR REPARATION
- 专利标题(中): 为Gewebsrückgewinnung软骨和骨形成材料
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申请号: EP96938460申请日: 1996-11-14
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公开(公告)号: EP0884052A4公开(公告)日: 1999-05-06
- 发明人: SHIMURA TAKESADA , TORIYAMA SATSUKI
- 申请人: HOECHST MARION ROUSSEL LTD
- 专利权人: HOECHST MARION ROUSSEL LTD
- 当前专利权人: HOECHST MARION ROUSSEL LTD
- 优先权: JP32240295 1995-11-17
- 主分类号: C12N15/09
- IPC分类号: C12N15/09 ; A61F2/02 ; A61F2/28 ; A61F2/30 ; A61K38/00 ; A61K38/18 ; A61K47/32 ; A61K47/34 ; A61L27/22 ; A61P3/00 ; A61P43/00 ; C07K14/51 ; C12P21/02 ; C12R1/19 ; A61B17/56 ; A61M37/00
摘要:
Cartilage/bone inducing materials for reparation which contain a bone inducer and polyoxyethylene polyoxypropylene glycol. In a particularly preferable example, the molecular weight of the polypropylene glycol constituting the polyoxyethylene polyoxypropylene glycol falls within the range of from about 1,500 to 4,000, the weight ratio of the ethylene oxide units falls within the range of from about 40 to 80 %/molecule, and the concentration of the polyoxyethylene polyoxypropylene glycol is about 10 to 50 % based on the aqueous solution. These materials are used in the cartilage/bone induction method without requiring any operation. Because of being composed of a bone inducer and a carrier which is easily absorbed in vivo, highly compatible with the bone inducer and undergoes reversible sol-gel change depending on the temperature, they can be highly applicable to fracture and bone-defective sites and thus exert excellent therapeutic effects.
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