发明公开
- 专利标题: SUBSTITUTED 1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES
- 专利标题(中): 替代物1,2,3,4-四氢萘基衍生物
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申请号: EP97914727.0申请日: 1997-03-20
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公开(公告)号: EP0888319A1公开(公告)日: 1999-01-07
- 发明人: BERG, Stefan , FLORVALL, Lennart , ROSS, Svante , THORBERG, Seth-Olov
- 申请人: Astra Aktiebolag
- 申请人地址: 151 85 Södertälje SE
- 专利权人: Astra Aktiebolag
- 当前专利权人: Astra Aktiebolag
- 当前专利权人地址: 151 85 Södertälje SE
- 优先权: SE19960001110 19960322
- 国际公布: WO1997034883 19970925
- 主分类号: C07D295
- IPC分类号: C07D295 ; A61K31 ; A61P9 ; A61P25 ; A61P43 ; C07D211 ; C07D241
摘要:
New piperidinyl- or piperazinyl-substituted-1,2,3,4-tetrahydronaphthalene derivatives having formula (I) wherein X is N or CH; Y is NR2CH2, CH2-NR2, NR2-CO, CO-NR2 or NR2SO2; R1 is H, C1-C6 alkyl or C3-C6 cycloalkyl; R3 is C1-C6 alkyl, C3-C6 cycloalkyl or (CH2)n-aryl, where aryl is phenyl or a heteroaromatic ring containing one or two heteroatoms selected from N, O and S and which may be mono- or di-substituted; n is 0-4; as (R)-enantiomer, (S)-enantiomer or a racemate in the form of the free base or a pharmaceutically acceptable salt or hydrate thereof; a pharmaceutical formulation containing the compounds, use of the compounds in the treatment of 5-hydroxytryptamine mediated disorders, processes for the preparation of the compounds and intermediates for the preparation of the compounds.
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