发明公开
EP0891338A1 BIOCONJUGATES OF MANGANESE OR IRON COMPLEXES OF NITROGEN-CONTAINING MACROCYCLIC LIGANDS EFFECTIVE AS CATALYSTS FOR DISMUTATING SUPEROXIDE
失效
MANGANEN或氮 - 大环含配体铁配合物的生物结合物用作催化剂FOR超氧的歧化
- 专利标题： BIOCONJUGATES OF MANGANESE OR IRON COMPLEXES OF NITROGEN-CONTAINING MACROCYCLIC LIGANDS EFFECTIVE AS CATALYSTS FOR DISMUTATING SUPEROXIDE
- 专利标题（中）： MANGANEN或氮 - 大环含配体铁配合物的生物结合物用作催化剂FOR超氧的歧化
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申请号： EP97907685.0申请日： 1997-03-04
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公开(公告)号： EP0891338A1公开(公告)日： 1999-01-20
- 发明人: NEUMANN, William, L. , RILEY, Dennis, P. , WEISS, Randy, H. , HENKE, Susan, L. , LENNON, Patrick, J. , ASTON, Karl, W.
- 申请人： MONSANTO COMPANY
- 申请人地址： 800 North Lindbergh Boulevard St. Louis, Missouri 63167 US
- 专利权人： MONSANTO COMPANY
- 当前专利权人： MONSANTO COMPANY
- 当前专利权人地址： 800 North Lindbergh Boulevard St. Louis, Missouri 63167 US
- 代理机构： Beil, Hans Christoph, Dr,, et al
- 优先权： US19960013348P 19960313; WO1996US12767 19960814
- 国际公布： WO1997033877 19970918
- 主分类号： A61K31
- IPC分类号： A61K31 ; A61K47 ; A61P1 ; A61P9 ; A61P39 ; A61P43 ; C07D259 ; C07F13 ; C07F15
摘要：
Bioconjugates of low molecular weight mimics of superoxide dismutase (SOD) represented by formula (I) wherein R, R', R1, R'1, R2, R'2, R3, R'3, R4, R'4, R5, R'5, R6, R'6, R7, R'7, R8, R'8, R9, R'9, X, Y, Z, M and n are as defined herein, useful as therapeutic agents for inflammatory disease states and disorders, such as ischemic/reperfusion injury, stroke, atherosclerosis, and all other conditions of oxidant-induced tissue damage or injury.
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