发明公开
- 专利标题: 5H-Thiazolo (3,2-a) pyrimidine derivatives
- 专利标题(中): 5H-噻唑并(3,2-a)嘧啶衍生物
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申请号: EP98112915.8申请日: 1998-07-11
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公开(公告)号: EP0891978A3公开(公告)日: 1999-02-03
- 发明人: Adam, Geo , Kolczewski, Sabine , Mutel, Vincent , Wichmann, Jürgen , Woltering, Thomas Johannes
- 申请人: F. HOFFMANN-LA ROCHE AG
- 申请人地址: 4070 Basel CH
- 专利权人: F. HOFFMANN-LA ROCHE AG
- 当前专利权人: F. HOFFMANN-LA ROCHE AG
- 当前专利权人地址: 4070 Basel CH
- 代理机构: Poppe, Regina
- 优先权: EP97112324 19970718
- 主分类号: C07D513/04
- IPC分类号: C07D513/04 ; A61K31/505 ; C07D239/40
摘要:
The invention is concerned with compounds of the general formula
wherein
R 1 signifies hydrogen, lower alkyl, phenyl or benzyl, R 2 signifies lower alkyl, lower alkoxy, -O(CH 2 ) n N(R 13 )(R 14 ), -(CH 2 ) n N(R 13 )(R 14 ) or -N(R 15 )(CH 2 ) n N(R 13 )(R 14 ), R 3 -R 12 signify hydrogen, halogen, trifluoromethyl, lower alkyl, cycloalkyl, lower alkoxy, hydroxy, nitro, cyano, -N(R 13 ) 2 , phenyl, phenyloxy, benzyl or benzyloxy, or R 6 and R 7 together signify a benzene ring, R 13 -R 15 signify hydrogen, lower alkyl or cycloalkyl and n signifies 1-5, as well as their pharmaceutically acceptable salts. These compounds are suitable for the control or prevention of acute and/or chronic neurological disorders such as restricted brain function caused by bypass operations or transplants, poor blood supply to the brain, spinal cord injuries, head injuries, hypoxia caused by pregnancy, cardiac arrest, hypoglycaemia, Alzheimer's disease,Huntington's chorea, ALS, dementia caused by AIDS, eye injuries, retinopathy, cognitive disorders, idiopathic parkinsonism or parkinsonism caused by medicaments as well as conditions which lead to glutamate-deficiency functions, such as e.g. muscle spasms, convulsions, migraine, urinary incontinence, nicotine addiction, psychoses, opiate addiction, anxiety, vomiting, chronic pain, dyskinesia and depressions.
wherein
R 1 signifies hydrogen, lower alkyl, phenyl or benzyl, R 2 signifies lower alkyl, lower alkoxy, -O(CH 2 ) n N(R 13 )(R 14 ), -(CH 2 ) n N(R 13 )(R 14 ) or -N(R 15 )(CH 2 ) n N(R 13 )(R 14 ), R 3 -R 12 signify hydrogen, halogen, trifluoromethyl, lower alkyl, cycloalkyl, lower alkoxy, hydroxy, nitro, cyano, -N(R 13 ) 2 , phenyl, phenyloxy, benzyl or benzyloxy, or R 6 and R 7 together signify a benzene ring, R 13 -R 15 signify hydrogen, lower alkyl or cycloalkyl and n signifies 1-5, as well as their pharmaceutically acceptable salts. These compounds are suitable for the control or prevention of acute and/or chronic neurological disorders such as restricted brain function caused by bypass operations or transplants, poor blood supply to the brain, spinal cord injuries, head injuries, hypoxia caused by pregnancy, cardiac arrest, hypoglycaemia, Alzheimer's disease,Huntington's chorea, ALS, dementia caused by AIDS, eye injuries, retinopathy, cognitive disorders, idiopathic parkinsonism or parkinsonism caused by medicaments as well as conditions which lead to glutamate-deficiency functions, such as e.g. muscle spasms, convulsions, migraine, urinary incontinence, nicotine addiction, psychoses, opiate addiction, anxiety, vomiting, chronic pain, dyskinesia and depressions.
公开/授权文献
- EP0891978B1 5H-Thiazolo (3,2-a) pyrimidine derivatives 公开/授权日:2002-03-20
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