发明公开
- 专利标题： ARZNEIMITTEL FÜR DIE BEHANDLUNG VON TUMORERKRANKUNGEN
- 专利标题（英）： Drug for the treatment of tumours
- 专利标题（中）： 药物的肿瘤疾病含TGF-β和Ras活化抑制剂抑制剂的治疗
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申请号： EP97916436.0申请日： 1997-04-04
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公开(公告)号： EP0896543A1公开(公告)日： 1999-02-17
- 发明人: BEUG, Hartmut , OFT, Martin , REICHMANN, Ernst , HEIDER, Karl-Heinz
- 申请人： Boehringer Ingelheim International GmbH
- 申请人地址： Postfach 200 55216 Ingelheim DE
- 专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人地址： Postfach 200 55216 Ingelheim DE
- 代理机构： Laudien, Dieter, Dr.
- 优先权： DE19961013691 19960405
- 国际公布： WO1997037678 19971016
- 主分类号： A61K45
- IPC分类号： A61K45 ; A61K31 ; A61K38 ; A61K39 ; A61K48 ; A61P11 ; A61P13 ; A61P35
摘要：
The invention concerns a drug containing as its active constituent a substance which inhibits the action of TGFβ on tumour cells of epithelial origin for the treatment of epithelial, invasive tumours characterized by a reversible transition of the cells from an epithelial, non-invasive state to a fibroblastic, invasive state. The drug contains a TGFβ inhibitor, preferably in combination with a Ras inhibitor. The invention also concerns a method of screening substances for the treatment of epithelial, invasive tumours.
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