发明公开
- 专利标题： DEATH DOMAIN CONTAINING RECEPTORS
- 专利标题（中）： 含有死亡受体的受体
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申请号： EP96941942.0申请日： 1996-10-17
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公开(公告)号： EP0898576A1公开(公告)日： 1999-03-03
- 发明人: YU, Guo-Liang , NI, Jian , DIXIT, Vishva, M. , GENTZ, Reiner, L. , DILLON, Patrick, J.
- 申请人： HUMAN GENOME SCIENCES, INC. , THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- 申请人地址： 9410 Key West Avenue Rockville, MD 20850-3338 US
- 专利权人： HUMAN GENOME SCIENCES, INC.,THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- 当前专利权人： HUMAN GENOME SCIENCES, INC.,THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- 当前专利权人地址： 9410 Key West Avenue Rockville, MD 20850-3338 US
- 代理机构： VOSSIUS & PARTNER
- 优先权： US19960013285P 19960312
- 国际公布： WO1997033904 19970918
- 主分类号： C12N15
- IPC分类号： C12N15 ; A61K38 ; A61P29 ; A61P31 ; A61P35 ; A61P37 ; A61P43 ; C07H21 ; C07K14 ; C12N1 ; C12N5 ; C12P21 ; C12R1
摘要：
The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.
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