发明授权
- 专利标题： Process for the preparation of microparticles
- 专利标题（中）： 一种用于制备微粒的方法
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申请号： EP97923063.8申请日： 1997-05-06
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公开(公告)号： EP0904063B1公开(公告)日： 2002-09-04
- 发明人: RICKEY, Michael, E. , RAMSTACK, J., Michael , LEWIS, Danny, H. , MESENS, Jean, Louis
- 申请人： Alkermes Controlled Therapeutics Inc. II , JANSSEN PHARMACEUTICA N.V.
- 申请人地址： 64 Sidney Street Cambridge, MA 02139-4136 US
- 专利权人： Alkermes Controlled Therapeutics Inc. II,JANSSEN PHARMACEUTICA N.V.
- 当前专利权人： Alkermes Controlled Therapeutics Inc. II,JANSSEN PHARMACEUTICA N.V.
- 当前专利权人地址： 64 Sidney Street Cambridge, MA 02139-4136 US
- 代理机构： Van Borm, Werner
- 优先权： US643919 19960507
- 国际公布： WO97041837 19971113
- 主分类号： A61K9/16
- IPC分类号： A61K9/16 ; A61K9/50
摘要：
The invention provides a process for the preparation of biodegradable biocompatible microparticles, said process comprising: contacting microparticles comprising a biodegradable biocompatible polymer matrix containing an active (e.g. pharmaceutical or diagnostic) agent and an organic solvent with an aqueous solvent system whereby the content of said organic solvent in said particles is reduced to 2 % or less of the weight of said particles, said solvent system being such as to satisfy at least one of the conditions (a) that it is at an elevated temperature (e.g. from 25 to 40 °C) during at least part of the time that it is in contact with said particles, and (b) that it comprises water and water-miscible solvent for said organic solvent; and recovering said particles from said aqueous solvent system.
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