发明授权
- 专利标题： ANTIVIRAL 2,4-PYRIMIDINEDIONE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF
- 专利标题（中）： 抗病毒2.4嘧啶二酮衍生物和工艺及其
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申请号： EP97920976.4申请日： 1997-05-15
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公开(公告)号： EP0912526B1公开(公告)日： 2003-03-05
- 发明人: SON, Jong, Chan , LEE, Ill, Young , KIM, Hyun, Sook , KIM, Jin, Chel , CHO, Eui, Hwan , CHUNG, Sun, Gan , KIM, Joung, Young , LEE, Soon, Hwan , KWON, Ho, Seok , LEE, Jae, Weung
- 申请人： Korea Research Institute of Chemical Technology , Samjin Pharmaceutical Co., Ltd.
- 申请人地址： 100, Jang-dong, Yuseong-gu Daejeon 305-343 KR
- 专利权人： Korea Research Institute of Chemical Technology,Samjin Pharmaceutical Co., Ltd.
- 当前专利权人： Korea Research Institute of Chemical Technology,Samjin Pharmaceutical Co., Ltd.
- 当前专利权人地址： 100, Jang-dong, Yuseong-gu Daejeon 305-343 KR
- 代理机构： Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät
- 优先权： KR9616413 19960516; KR9713560 19970414
- 国际公布： WO97043266 19971120
- 主分类号： C07D239/54
- IPC分类号： C07D239/54 ; C07D239/545 ; A61K31/505
摘要：
6-aryloxy and 6-arylcarbonyl 2,4-pyrimidinedione derivatives of formula (I) having high antiviral activity against HIV-1 and low toxicity are useful for treating AIDS, wherein R1 is hydrogen or a C¿1-10? alkyl group optionally having a substituent selected from the group consisting of aryl, hydroxy, C1-10 alkoxy and C2-5 alkylcarbonyloxy groups; R?2¿ is hydrogen or a C¿1-10? alkyl group optionally having an aryl substituent; R?3 and R4¿ are each hydrogen or a C¿1-3? alkyl group; and A is oxygen or a carbonyl group.
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