发明公开
EP0914346A1 THERAPEUTIC MULTISPECIFIC COMPOUNDS COMPRISED OF ANTI-FC$g(a) RECEPTOR ANTIBODIES
失效
抗体对的FC-α受体治疗性多具体化合物含有
- 专利标题： THERAPEUTIC MULTISPECIFIC COMPOUNDS COMPRISED OF ANTI-FC$g(a) RECEPTOR ANTIBODIES
- 专利标题（中）： 抗体对的FC-α受体治疗性多具体化合物含有
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申请号： EP97934094.0申请日： 1997-07-10
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公开(公告)号： EP0914346A1公开(公告)日： 1999-05-12
- 发明人: DEO, Yashwant, M. , GRAZIANO, Robert , KELER, Tibor
- 申请人： Medarex, Inc.
- 申请人地址： 1545 Route 22 East, P.O. Box 992 Annandale, NJ 08801-0992 US
- 专利权人： Medarex, Inc.
- 当前专利权人： Medarex, Inc.
- 当前专利权人地址： 1545 Route 22 East, P.O. Box 992 Annandale, NJ 08801-0992 US
- 代理机构： Price, Vincent Andrew, et al
- 优先权： US19960678194 19960711
- 国际公布： WO1998002463 19980122
- 主分类号： C12N15
- IPC分类号： C12N15 ; A61K31 ; A61K39 ; A61P31 ; A61P35 ; C07K14 ; C07K16 ; C07K19 ; C12P21 ; G01N33 ; A61K38
摘要：
Multispecific compounds comprising at least one binding determinant which binds to the Fcx-receptor on an effector cell. The other binding determinant(s) binds(s) to one or more antigens on a target cell, e.g., the Neu/Her-2 proto-oncogene product or the epidermal growth factor receptor on cancer cells, or to Candida antigens on infected cells. Examples are biospecific and trispecific antibodies. Therapeutic use of said multispecific compounds for treatment of cancers or pathogen infections.
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