发明公开
EP0920518A1 STIMULUS-INDUCIBLE I (KAPPA)B KINASE IKK] SIGNALSOME
失效
VON EINEM刺激感染犬I（KAPPA）B激酶KOMPLEX
- 专利标题： STIMULUS-INDUCIBLE I (KAPPA)B KINASE IKK] SIGNALSOME
- 专利标题（中）： VON EINEM刺激感染犬I（KAPPA）B激酶KOMPLEX
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申请号： EP97938616.0申请日： 1997-08-26
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公开(公告)号： EP0920518A1公开(公告)日： 1999-06-09
- 发明人: MERCURIO, Frank , ZHU, Hengyi , BARBOSA, Miguel , LI, Gian , MURRAY, Brion, W.
- 申请人： SIGNAL PHARMACEUTICALS, INC.
- 申请人地址： 5555 Oberlin Drive San Diego, CA 92121 US
- 专利权人： SIGNAL PHARMACEUTICALS, INC.
- 当前专利权人： SIGNAL PHARMACEUTICALS, INC.
- 当前专利权人地址： 5555 Oberlin Drive San Diego, CA 92121 US
- 代理机构： Gowshall, Jonathan Vallance, et al
- 优先权： US19960697393 19960826; US19970910820 19970813
- 国际公布： WO1998008955 19980305
- 主分类号： G01N33
- IPC分类号： G01N33 ; A61K38 ; A61K39 ; A61K45 ; A61K48 ; A61P43 ; C07K14 ; C07K16 ; C12N1 ; C12N5 ; C12N9 ; C12N15 ; C12P21 ; C12Q1
摘要：
Compositions and methods are provided for treating NF-λB-related conditions. In particular, the invention provides a stimulus-inducible IKK signalsome, and components and variants thereof. An IKK signalsome or component thereof may be used, for example, to identify antibodies and other modulating agents that inhibit or activate signal transduction via the NF-λB cascade. IKK signalsome, components thereof and/or modulating agents may also be used for the treatment of diseases associated with NF-λB activation.
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