发明公开
- 专利标题： A VECTOR FOR POLYNUCLEOTIDE VACCINES
- 专利标题（中）： 多核苷酸疫苗的一种载体
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申请号： EP97937243.0申请日： 1997-08-14
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公开(公告)号： EP0920522A1公开(公告)日： 1999-06-09
- 发明人: NELSON, Edward, L. , NELSON, Peter, J.
- 申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
- 申请人地址： National Institute of Health, Office of Technology Transfer, 6011 Executive Boulevard, Suite 325 Rockville, MD 20852-3804 US
- 专利权人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
- 当前专利权人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
- 当前专利权人地址： National Institute of Health, Office of Technology Transfer, 6011 Executive Boulevard, Suite 325 Rockville, MD 20852-3804 US
- 代理机构： Vossius, Volker, Dr., et al
- 优先权： US19960023931P 19960814
- 国际公布： WO1998006863 19980219
- 主分类号： C07K14
- IPC分类号： C07K14 ; C12N15
摘要：
The invention is a "humanized" polynucleotide vector vaccine which uses covalent closed circular plasmid DNA, "naked DNA", to express target antigens. The vector is non-replicating in mammalian cells but is capable of extended stable expression of the target sequences in skeletal muscle and professional antigen presenting cells generating an immune response to the target antigen in immunized individuals. The polynucleotide vector is particularly useful in accommodating monomorphic and polymorphic nucleic acid sequences encoding tumor antigens via PCR technology.
公开/授权文献
- EP0920522B1 A VECTOR FOR POLYNUCLEOTIDE VACCINES 公开/授权日：2003-10-29
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