发明公开
- 专利标题: HIGH LEVEL EXPRESSION OF PROTEINS
- 专利标题(中): 蛋白表达率高
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申请号: EP97941703.0申请日: 1997-09-18
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公开(公告)号: EP0929564A1公开(公告)日: 1999-07-21
- 发明人: SEED, Brian , HAAS, Jurgen
- 申请人: THE GENERAL HOSPITAL CORPORATION
- 申请人地址: 55 Fruit Street Boston, MA 02110 US
- 专利权人: THE GENERAL HOSPITAL CORPORATION
- 当前专利权人: THE GENERAL HOSPITAL CORPORATION
- 当前专利权人地址: 55 Fruit Street Boston, MA 02110 US
- 代理机构: Jacobi, Markus Alexander, et al
- 优先权: US19960717294 19960920
- 国际公布: WO1998012207 19980326
- 主分类号: C12N15
- IPC分类号: C12N15 ; C07K14 ; C12N5 ; C12P21 ; C12R1
摘要:
The invention features a synthetic gene encoding a protein normally expressed in a mammalian cell wherein at least one non-preferred or less preferred codon in the natural gene encoding the protein has been replaced by a preferred codon encoding the same amino acid.
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