发明公开
- 专利标题： INTEGRIN ANTAGONISTS
- 专利标题（中）： 整合
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申请号： EP97938568.0申请日： 1997-08-25
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公开(公告)号： EP0934305A1公开(公告)日： 1999-08-11
- 发明人: DUGGAN, Mark, E. , HARTMAN, George, D. , HOFFMAN, William, F. , MEISSNER, Robert, S. , PERKINS, James, J. , ASKEW, Ben, C. , COLEMAN, Paul, J. , HUTCHINSON, John, H. , NAYLOR-OLSEN, Adel, M.
- 申请人： MERCK & CO., INC.
- 申请人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065 US
- 专利权人： MERCK & CO., INC.
- 当前专利权人： MERCK & CO., INC.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065 US
- 代理机构： Horgan, James Michael Frederic, et al
- 优先权： US19960025123P 19960829; US19960033579P 19961219; GB19970003015 19970213; US19970047177P 19970520
- 国际公布： WO1998008840 19980305
- 主分类号： A61K31
- IPC分类号： A61K31 ; A61P3 ; A61P9 ; A61P19 ; A61P27 ; A61P29 ; A61P35 ; A61P43 ; C07D471 ; C07D519 ; C07K5 ; A61K38
摘要：
This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as vitronectin receptor antagonists. The vitronectin receptor antagonist compounds of the present invention are αvβ3 antagonists, αvβ5 antagonists or dual αvβ3/αvβ5 antagonists useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation and tumor growth.
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