发明公开
- 专利标题： Pyrrolidine and piperidine derivatives
- 专利标题（中）： 吡咯烷和哌啶衍生物
-
申请号： EP99102078.5申请日： 1999-02-02
-
公开(公告)号： EP0937458A2公开(公告)日： 1999-08-25
- 发明人: Alanine, Alexander , Buettelmann, Bernd , Heitz Neidhart, Marie-Paule , Pinard, Emmanuel , Wyler, René
- 申请人： F. HOFFMANN-LA ROCHE AG
- 申请人地址： 4070 Basel CH
- 专利权人： F. HOFFMANN-LA ROCHE AG
- 当前专利权人： F. HOFFMANN-LA ROCHE AG
- 当前专利权人地址： 4070 Basel CH
- 代理机构： Poppe, Regina
- 优先权： EP98102246 19980210
- 主分类号： A61K31/40
- IPC分类号： A61K31/40 ; A61K31/445 ; A61K31/42 ; A61K31/535
摘要：
The present invention relates to the use of pyrrolidine and piperidine derivatives of the general formulae
wherein
R 1 and R 2 are, independently from each other, hydrogen, lower alkoxy, hydroxy, halogen, -CONH 2 or -C(O)O-lower alkyl; or taken together are -O-CH 2 -O-;
R 3 and R 4 are, independently from each other, hydrogen, lower alkoxy, benzyloxy, halogen, hydroxy, -CONH 2 or -SCH 3 ; or taken together are -O-CH 2 -O-;
R 5 is hydrogen or lower alkyl;
X and Y are, independently from each other -CH(OH)-, -(CH 2 ) n -, -C(O)- or -CH(lower alkoxy)-; and
m, n and p are 1 or 2;
and to their pharmaceutically acceptable addition salts for the treatment of diseases caused by overactivation of NMDA receptor subtypes.
wherein
R 1 and R 2 are, independently from each other, hydrogen, lower alkoxy, hydroxy, halogen, -CONH 2 or -C(O)O-lower alkyl; or taken together are -O-CH 2 -O-;
R 3 and R 4 are, independently from each other, hydrogen, lower alkoxy, benzyloxy, halogen, hydroxy, -CONH 2 or -SCH 3 ; or taken together are -O-CH 2 -O-;
R 5 is hydrogen or lower alkyl;
X and Y are, independently from each other -CH(OH)-, -(CH 2 ) n -, -C(O)- or -CH(lower alkoxy)-; and
m, n and p are 1 or 2;
and to their pharmaceutically acceptable addition salts for the treatment of diseases caused by overactivation of NMDA receptor subtypes.
公开/授权文献
- EP0937458B1 Pyrrolidine and piperidine derivatives 公开/授权日：2004-12-29
信息查询
