Disclosed are compounds of formula (I) wherein W is CH or N; R is (mono- or di-carbocyclic or heterocyclic aryl)-lower alkyl; R1 is hydrogen or lower alkyl; R?2 and R3¿ are hydrogen, lower alkyl, lower alkoxy-lower alkyl or aryl-lower alkyl; or R?2 and R3¿ joined together represent lower alkylene optionally interrupted by O, NH, N-lower alkyl or S so as to form a ring with the amide nitrogen; X is O, S, SO, SO¿2? or a direct bond; X?1¿ is O, S, SO, SO¿2? or a direct bond; Y is a direct bond, lower alkylene or lower alkylidene; and Z is carboxyl, 5-tetrazolyl, hydroxymethyl or carboxyl derivatized in the form of a pharmaceutically acceptable ester; and pharmaceutically acceptable salts thereof; which are useful as LTB-4 antagonists.