发明授权
- 专利标题： COMPOUNDS USEFUL FOR INHIBITION OF FARNESYL PROTEIN TRANSFERASE
- 专利标题（中）： 化合物作为抑制剂法尼基转移
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申请号： EP97955043.1申请日： 1997-09-11
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公开(公告)号： EP0942906B1公开(公告)日： 2004-11-03
- 发明人: NJOROGE, F., George , TAVERAS, Arthur, G. , DOLL, Ronald, J. , LALWANI, Tarik , ALVAREZ, Carmen , REMISZEWSKI, Stacy, W.
- 申请人： SCHERING CORPORATION
- 申请人地址： 2000 Galloping Hill Road Kenilworth, New Jersey 07033-0530 US
- 专利权人： SCHERING CORPORATION
- 当前专利权人： SCHERING CORPORATION
- 当前专利权人地址： 2000 Galloping Hill Road Kenilworth, New Jersey 07033-0530 US
- 代理机构： Ritter, Stephen David
- 优先权： US710225 19960913; US877453 19970617
- 国际公布： WO1998030558 19980716
- 主分类号： C07D401/04
- IPC分类号： C07D401/04 ; A61K31/55 ; C07D401/14
摘要：
Novel tricyclic compounds of Formula (1.0) are disclosed. Compounds of Formula (1.0) are represented by the compounds of formulas (1.4) or (1.5) wherein R?1, R3 and R4¿ are each independently selected from halo. Also disclosed are methods of inhibiting farnesyl protein transferase and the growth of abnormal cells, such as tumor cells.
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