发明公开
- 专利标题： MODULATION OF INTERACTIONS BETWEEN MYOSIN AND INTEGRINS
- 专利标题（中）： 调制肌球蛋白之间的整合和相互作用的
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申请号： EP97952309.0申请日： 1997-11-21
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公开(公告)号： EP0942931A2公开(公告)日： 1999-09-22
- 发明人: JENKINS, Alison, L. , PHILLIPS, David, R.
- 申请人： COR THERAPEUTICS, INC.
- 申请人地址： 256 East Grand Avenue, Suite 80 South San Francisco, CA 94080 US
- 专利权人： COR THERAPEUTICS, INC.
- 当前专利权人： COR THERAPEUTICS, INC.
- 当前专利权人地址： 256 East Grand Avenue, Suite 80 South San Francisco, CA 94080 US
- 代理机构： Mouget-Goniot, Claire, et al
- 优先权： US19960031665P 19961121; US19970042093P 19970328; US19970975653 19971121
- 国际公布： WO1998022500 19980528
- 主分类号： A61K45
- IPC分类号： A61K45 ; A61K38 ; A61P7 ; A61P9 ; A61P21 ; A61P29 ; A61P35 ; C07K14
摘要：
The present invention describes a direct interaction between myosin and the cytoplasmic domain of membrane proteins, particularly the phosphorylated cytoplasmic domains of the β-subunit of integrins. The invention provides methods of identifying agents which block integrin binding to myosin, methods of using agents which block integrin binding to myosin to modulate biological and pathological processes, and provides agents that block integrin mediated binding to myosin and thereby modulate related cellular or cellular component movement.
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