发明公开
EP0946203A4 TRICYCLIC FUNCTIONAL DYES FOR CONTRAST ENHANCEMENT IN OPTICAL IMAGING
失效
三环功能染料对比度和光学成像的改进
- 专利标题: TRICYCLIC FUNCTIONAL DYES FOR CONTRAST ENHANCEMENT IN OPTICAL IMAGING
- 专利标题(中): 三环功能染料对比度和光学成像的改进
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申请号: EP97924639申请日: 1997-05-09
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公开(公告)号: EP0946203A4公开(公告)日: 2000-03-29
- 发明人: FUNG ELLA Y , RAJAGOPALAN RAGHAVAN
- 申请人: MALLINCKRODT INC
- 专利权人: MALLINCKRODT INC
- 当前专利权人: MALLINCKRODT INC
- 优先权: US64537696 1996-05-13
- 主分类号: C07D277/64
- IPC分类号: C07D277/64 ; A61K49/00 ; C07D235/06 ; C07D293/10 ; C07D293/12 ; C07D417/14 ; G01N31/00 ; G01N33/48
摘要:
This invention provides functional dyes of general formula (1) wherein R?1, R2, and R5¿ may be the same or different and are selected from the group consisting of hydrogen, C¿1?-C10 alkyl, C1-C10 alkoxyl, hydroxyl, C1-C10 hydroxyalkyl, C1-C10 alkoxyalkyl, C1-C10 aryl, carboxyl, C1-C10 carboxylalkyl, halogen, nitro, C1-C10 alkoxycarbonyl, mercapto, C1-C10 mercaptoalkyl, C1-C10 alkylthio, sulfonate, and -(CH2)m-N(R?6)(R7¿) wherein R?6 and R7¿ are independently hydrogen or C¿1?-C10 alkyl, C1-C10 acyl, and R?6 and R7¿ are capable of forming 5, 6, or 7 membered rings which may optionally be substituted with -O-, -NR8, or -S-; R?3 and R4¿ may be the same or different and are selected from the group consisting of C¿1?-C10 alkyl, C1-C10 hydroxyalkyl, C1-C10 alkoxyalkyl, C1-C10 aryl, C1-C10 carboxylalkyl, C1-C10 alkyl sulfonate, mercapto alkyl and -(CH2)mN(R?6)(R7); W1 and W2¿ may be the same or different and are selected from the group consisting of -S-, -O-, -Se-, -Te-, -NR8 and C(R9)(R10); and m is about 0-10; R8 is hydrogen, C¿1?-C10 alkyl, C1-C10 alkoxy, C1-C10 mercaptoalkyl, hydroxyl, C1-C10 hydroxyalkyl, C1-C10 alkoxyalkyl, C1-C10 aryl, C1-C10 carboxylalkyl, C1-C10 alkoxycarbonyl, C1-C10 alkylthio, and -(CH2)m-N(R?6)(R7); R9 and R10¿ are independently hydrogen, C¿1?-C10 alkyl, C1-C10 alkoxyl, C1-C10 hydroxyalkyl, C1-C10 alkoxyalkyl, C1-C10 carboxyalkyl, C1-C10 alkoxycarbonyl, and -(CH2)m-N(R?6)(R7¿); and A is selected from the group consisting of -(CH¿2?)m, -C(R?9)(R10¿), -(CH¿2?)m-N(R?6)(R7¿), -O-, -S-, or -NR8.
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