发明授权
EP0946203B1 TRICYCLIC FUNCTIONAL DYES FOR CONTRAST ENHANCEMENT IN OPTICAL IMAGING
失效
三环功能染料对比度和光学成像的改进
- 专利标题： TRICYCLIC FUNCTIONAL DYES FOR CONTRAST ENHANCEMENT IN OPTICAL IMAGING
- 专利标题（中）： 三环功能染料对比度和光学成像的改进
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申请号： EP97924639.4申请日： 1997-05-09
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公开(公告)号： EP0946203B1公开(公告)日： 2002-07-24
- 发明人: FUNG, Ella, Y. , RAJAGOPALAN, Raghavan
- 申请人： MALLINCKRODT, INC.
- 申请人地址： P.O. Box 5840 675 McDonnell Blvd. St. Louis, MO 63134 US
- 专利权人： MALLINCKRODT, INC.
- 当前专利权人： MALLINCKRODT, INC.
- 当前专利权人地址： P.O. Box 5840 675 McDonnell Blvd. St. Louis, MO 63134 US
- 代理机构： Jones, Alan John
- 优先权： US645376 19960513
- 国际公布： WO9742976 19971120
- 主分类号： A61K49/00
- IPC分类号： A61K49/00 ; G01N31/00 ; G01N33/48
摘要：
This invention provides functional dyes of general formula (1) wherein R?1, R2, and R5¿ may be the same or different and are selected from the group consisting of hydrogen, C¿1?-C10 alkyl, C1-C10 alkoxyl, hydroxyl, C1-C10 hydroxyalkyl, C1-C10 alkoxyalkyl, C1-C10 aryl, carboxyl, C1-C10 carboxylalkyl, halogen, nitro, C1-C10 alkoxycarbonyl, mercapto, C1-C10 mercaptoalkyl, C1-C10 alkylthio, sulfonate, and -(CH2)m-N(R?6)(R7¿) wherein R?6 and R7¿ are independently hydrogen or C¿1?-C10 alkyl, C1-C10 acyl, and R?6 and R7¿ are capable of forming 5, 6, or 7 membered rings which may optionally be substituted with -O-, -NR8, or -S-; R?3 and R4¿ may be the same or different and are selected from the group consisting of C¿1?-C10 alkyl, C1-C10 hydroxyalkyl, C1-C10 alkoxyalkyl, C1-C10 aryl, C1-C10 carboxylalkyl, C1-C10 alkyl sulfonate, mercapto alkyl and -(CH2)mN(R?6)(R7); W1 and W2¿ may be the same or different and are selected from the group consisting of -S-, -O-, -Se-, -Te-, -NR8 and C(R9)(R10); and m is about 0-10; R8 is hydrogen, C¿1?-C10 alkyl, C1-C10 alkoxy, C1-C10 mercaptoalkyl, hydroxyl, C1-C10 hydroxyalkyl, C1-C10 alkoxyalkyl, C1-C10 aryl, C1-C10 carboxylalkyl, C1-C10 alkoxycarbonyl, C1-C10 alkylthio, and -(CH2)m-N(R?6)(R7); R9 and R10¿ are independently hydrogen, C¿1?-C10 alkyl, C1-C10 alkoxyl, C1-C10 hydroxyalkyl, C1-C10 alkoxyalkyl, C1-C10 carboxyalkyl, C1-C10 alkoxycarbonyl, and -(CH2)m-N(R?6)(R7¿); and A is selected from the group consisting of -(CH¿2?)m, -C(R?9)(R10¿), -(CH¿2?)m-N(R?6)(R7¿), -O-, -S-, or -NR8.
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