发明授权
- 专利标题: NOVEL ETHYLAMINE DERIVATIVES
- 专利标题(中): NEW乙胺
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申请号: EP98935352.9申请日: 1998-08-03
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公开(公告)号: EP0957080B1公开(公告)日: 2006-06-21
- 发明人: YONEDA, Fumio, Soyaku Kenkyusyo , KNOLL, Joseph , ODE, Hironori, Soyaku Kenkyusho , SAKAE, Masatoshi, Soyaku Kenkyusho , KATURADA, Masanori, Soyaku Kenkyusho , MOTO, Toshiaki, Soyaku Kenkyusho , ANDO, Takashi, Soyaku Kenkyusho , SHIMAZU, Seiichiro, Soyaku Kenkyusho , TAKAHATA, Kazue, Soyaku Kenkyusho , FUJIMOTO, Michitaro, Fujimoto Pharma. Co., Ltd.
- 申请人: Fujimoto Brothers Co., Ltd.
- 申请人地址: 3-40, Nishiotuka 1-chome Matubara-shi, Osaka 580-0011 JP
- 专利权人: Fujimoto Brothers Co., Ltd.
- 当前专利权人: Fujimoto Brothers Co., Ltd.
- 当前专利权人地址: 3-40, Nishiotuka 1-chome Matubara-shi, Osaka 580-0011 JP
- 代理机构: Prins, Adrianus Willem
- 优先权: JP24744597 19970807
- 国际公布: WO1999007667 19990218
- 主分类号: C07C211/30
- IPC分类号: C07C211/30 ; C07C233/05 ; C07D333/58 ; C07D307/79 ; C07D317/58 ; C07D319/18 ; C07D209/08 ; C07D209/14 ; A61K31/135 ; A61K31/165 ; A61K31/38 ; A61K31/39 ; A61K31/36 ; A61K31/335 ; A61K31/40
摘要:
Novel ethylamine derivatives represented by general formula (I) and pharmaceutically acceptable acid-addition salts thereof, wherein R1 represents hydrogen, hydroxy, lower alkoxy or halogeno; R2 represents C¿2-5? alkyl; R?3¿ represents hydrogen, C¿2-5? alkyl, C2-5 alkylcarbonyl, C6-10 aryl or C7-11 aralkyl; and the ring A means a bicyclic compound consisting of at least one benzene ring and a saturated or unsaturated 5- or 6-membered ring optionally containing heteroatom(s), provided that R?2 and R3¿ do not carry each two carbon atoms at the same time when the ring A is indole or 1,3-benzodioxole; and the ring A is a bicyclic compound other than indole or benzo[b]thiophene and R2 is a C¿3-5? alkyl when R?3¿ is hydrogen. Because of having catecholamine-potentiating effects and high selectivity for the CAE effect, these compounds are useful as psychotropic drugs, antidepressants, antiparkinson agents and antialzheimer agents.
公开/授权文献
- EP0957080A1 NOVEL ETHYLAMINE DERIVATIVES 公开/授权日:1999-11-17
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