发明授权
EP0960106B1 1-PHENYL-4-BENZYLPIPERAZINES: DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS (D4)
失效
1-苯基-4-苄基哌嗪：对多巴胺受体的特异性配体（D4）
- 专利标题： 1-PHENYL-4-BENZYLPIPERAZINES: DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS (D4)
- 专利标题（中）： 1-苯基-4-苄基哌嗪：对多巴胺受体的特异性配体（D4）
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申请号： EP98903796.5申请日： 1998-01-29
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公开(公告)号： EP0960106B1公开(公告)日： 2004-05-06
- 发明人: THURKAUF, Andrew , CHEN, Xi
- 申请人： NEUROGEN CORPORATION
- 申请人地址： 35 N.E. Industrial Road Branford, CT 06405 US
- 专利权人： NEUROGEN CORPORATION
- 当前专利权人： NEUROGEN CORPORATION
- 当前专利权人地址： 35 N.E. Industrial Road Branford, CT 06405 US
- 代理机构： Vossius, Volker, Dr.
- 优先权： US791673 19970130
- 国际公布： WO1998033784 19980806
- 主分类号： C07D295/06
- IPC分类号： C07D295/06 ; A61K31/495 ; C07D405/10
摘要：
Disclosed are compounds of formula (I) or the pharmaceutically acceptable addition salts thereof wherein: R1 is halogen or C1-C4 alkyl; and R2 and R3 are the same or different and represent hydrogen, halogen, C1-C4 alkyl, C1-C4 alkoxy, alkylthio, hydroxy, amino, mono(C1-C4)alkylamino, di(C1-C4)alkylamino, or R2 and R3 together represent a 4 carbon alkenylene moiety that together with the phenyl ring to which they are attached form a naphthyl moiety, which compounds are dopamine D4(ant)agonists and useful in the treatment of neuropsychological diseases such as schizophrenia, psychotic depression and mania.
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