发明公开
EP0964851A1 C-TERMINAL KETONE HYDROXAMIC ACID INHIBITORS OF MATRIX METALLOPROTEINASES AND TNFA SECRETION
失效
HYDROXAMSÄURENMIT C-TERMINALER KETOFUNKTION ALS HEMMER VON MATRIXMETALLOPROTEINASEN UND DER TNFA-SEKRETION
- 专利标题： C-TERMINAL KETONE HYDROXAMIC ACID INHIBITORS OF MATRIX METALLOPROTEINASES AND TNFA SECRETION
- 专利标题（中）： HYDROXAMSÄURENMIT C-TERMINALER KETOFUNKTION ALS HEMMER VON MATRIXMETALLOPROTEINASEN UND DER TNFA-SEKRETION
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申请号： EP98902771.0申请日： 1998-01-07
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公开(公告)号： EP0964851A1公开(公告)日： 1999-12-22
- 发明人: DAVIDSEN, Steven, K. , FLORJANCIC, Alan, Scott , SHEPPARD, George, S. , GIESLER, Jamie, R. , XU, Lianhong , GUO, Yan , CURTIN, Michael, L. , MICHAELIDES, Michael, R. , WADA, Carol, K. , HOLMS, James, H.
- 申请人： Abbott Laboratories
- 申请人地址： Chad 0377/AP6D-2, 100 Abbott Park Road Abbott Park, Illinois 60064-3500 US
- 专利权人： Abbott Laboratories
- 当前专利权人： Abbott Laboratories
- 当前专利权人地址： Chad 0377/AP6D-2, 100 Abbott Park Road Abbott Park, Illinois 60064-3500 US
- 代理机构： Modiano, Guido, Dr.-Ing., et al
- 优先权： US19970779778 19970107
- 国际公布： WO1998030541 19980716
- 主分类号： A61K31
- IPC分类号： A61K31 ; A61P19 ; A61P29 ; A61P35 ; A61P43 ; C07C233 ; C07C259 ; C07D207 ; C07D209 ; C07D213 ; C07D235 ; C07D263 ; C07D277 ; C07D333
摘要：
C-terminal compounds of formula (I) are potent inhibitors of matrix metalloproteinase and are useful in the treatment of diseases in which matrix metalloproteinase play a role. Also disclosed are matrix metalloproteinase inhibiting compositions and a method of inhibiting matrix metalloproteinase in a mammal.
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