发明公开
- 专利标题： VIRAL DEFECTIVE INTERFERING PARTICLES AND USES THEREOF
- 专利标题（中）： 缺陷型病毒寄生粒子和它们的用途。
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申请号： EP97941679.9申请日： 1997-09-18
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公开(公告)号： EP0969863A1公开(公告)日： 2000-01-12
- 发明人: SHIH, Chiaho , YUAN, Ta-Tung
- 申请人： The Board of Regents, The University of Texas Systems
- 申请人地址： 201 West 7th Street Austin, TX 78701 US
- 专利权人： The Board of Regents, The University of Texas Systems
- 当前专利权人： The Board of Regents, The University of Texas Systems
- 当前专利权人地址： 201 West 7th Street Austin, TX 78701 US
- 代理机构： Wilkinson, Stephen John
- 优先权： US26313P 19960918
- 国际公布： WO9811916 19980326
- 主分类号： A61K39/12
- IPC分类号： A61K39/12 ; A61K39/29 ; C12N7/00 ; C12N7/01 ; C12N7/04 ; C12N15/00
摘要：
The present invention provides a composition of matter comprising a defective interfering virus particle, wherein said particle naturally occurs in a human infection and wherein said particle has a naturally occurring core antigen internal deletion. Provided is a pharmaceutical composition, comprising defective interfering virus particle and a pharmaceutically acceptable carrier. Provided is a method for preparing defective intefering virus, comprising the steps of: (1) introducing a defective interfering virus and a complementing plasmid expressing a wild type virus core antigen and optionally containing a drug resistance gene, into a recipient cell; (2) selecting for stably tranfected colonies; (3) growing the drug resistant cells and screening for the production of virus DNA replication; and (4) collecting defective interfering virus particles from the medium. Further provided is a vaccine, comprising a defective interfering virus particle.
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