发明公开
EP0969865A1 MHC CLASS II ANTIGEN-PRESENTING SYSTEMS AND METHODS FOR ACTIVATING CD4?+ T CELLS
失效
SYSTEMS FOR MHC抗原II类激活CD4 +介绍和方法 - T淋巴细胞
- 专利标题： MHC CLASS II ANTIGEN-PRESENTING SYSTEMS AND METHODS FOR ACTIVATING CD4?+ T CELLS
- 专利标题（中）： SYSTEMS FOR MHC抗原II类激活CD4 +介绍和方法 - T淋巴细胞
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申请号： EP97927709.2申请日： 1997-05-22
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公开(公告)号： EP0969865A1公开(公告)日： 2000-01-12
- 发明人: WEBB, Susan, R. , WINQVIST, Ola , KARLSSON, Lars , JACKSON, Michael, R. , PETERSON, Per, A.
- 申请人： The Scripps Research Institute
- 申请人地址： 10550 North Torrey Pines Road La Jolla, CA 92037 US
- 专利权人： The Scripps Research Institute
- 当前专利权人： The Scripps Research Institute
- 当前专利权人地址： 10550 North Torrey Pines Road La Jolla, CA 92037 US
- 代理机构： Fisher, Adrian John
- 优先权： US18175P 19960523
- 国际公布： WO9746256 19971211
- 主分类号： A61K39/385
- IPC分类号： A61K39/385 ; A61K45/05 ; A61K48/00 ; C07K14/705
摘要：
The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC antigen-presenting molecules with one or more accessory molecules. The matrices are used to activate naive CD4+ T cells as well as shift the ongoing activation state into a preferred differentiated population of either Th1 or Th2 cells.
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