发明公开
- 专利标题： SYNTHESIS OF INTERMEDIATES USEFUL IN PREPARING TRICYCLIC COMPOUNDS
- 专利标题（中）： 合成中间体适用于三环化合物的制作
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申请号： EP98910084.7申请日： 1998-03-23
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公开(公告)号： EP0977739A1公开(公告)日： 2000-02-09
- 发明人: CHEN, Xing , POIRIER, Marc , WONG, Yee-Shing , WU, Guang-Zhong
- 申请人： SCHERING CORPORATION
- 申请人地址： 2000 Galloping Hill Road KenilworthNew Jersey 07033 US
- 专利权人： SCHERING CORPORATION
- 当前专利权人： SCHERING CORPORATION
- 当前专利权人地址： 2000 Galloping Hill Road KenilworthNew Jersey 07033 US
- 代理机构： von Kreisler, Alek, Dipl.-Chem.
- 优先权： US823928 19970325
- 国际公布： WO9842676 19981001
- 主分类号： C07D221/16
- IPC分类号： C07D221/16 ; C07D213/81 ; C07C25/02 ; C07C17/16
摘要：
The invention relates to a process for preparing a compound of formula (I), comprising reacting a bromo-substituted pyridine with an amine of the formula NHR5R6, reacting the resulting amide with an iodo-halomethyl-substituted compound and cyclizing the resultant product, wherein R, R?1, R2, R3 and R4¿ are as defined in the specification; also claimed are a compound of formula (a), and a process for preparing it from the corresponding halo-substituted benzoic acid.
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