发明公开
- 专利标题： Novel antimicrobial lactam-quinolones
- 专利标题（中）： 新型抗菌内酰胺 - 喹诺酮类
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申请号： EP99204491.7申请日： 1989-10-18
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公开(公告)号： EP0997466A1公开(公告)日： 2000-05-03
- 发明人: White, Ronald Eugene , Demuth Jr, Thomas Prosser
- 申请人： PROCTER & GAMBLE PHARMACEUTICALS, INC.
- 申请人地址： 17 Eaton Avenue Norwich, NY 13815 US
- 专利权人： PROCTER & GAMBLE PHARMACEUTICALS, INC.
- 当前专利权人： PROCTER & GAMBLE PHARMACEUTICALS, INC.
- 当前专利权人地址： 17 Eaton Avenue Norwich, NY 13815 US
- 代理机构： Kyle, Diana
- 优先权： US261948 19881024; US416645 19891010
- 主分类号： C07D501/20
- IPC分类号： C07D501/20 ; C07D499/00 ; C07D499/88 ; C07D401/12 ; C07D463/16 ; C07D477/14 ; C07D477/20 ; C07D503/00 ; C07D505/00 ; C07D513/04 ; C07D498/04 ; C07D487/04 ; A61K31/546 ; A61K31/431 ; A61P31/04
摘要：
Antimicrobial lactam-quinolone compounds comprising a lactam-containing moiety linked to a quinolone moiety, of the formula:
wherein
(1) A 1 , A 2 , A 3 , R 1 , R 4 and R 6 generally form any of a variety of quinolone, naphthyridine or related cyclic moieties known in the art to have antimicrobial activity; and
(2) R 1 or R 3 contain a linking moiety, linking the quinolone moiety to a lactam-containing moiety having the formula:
wherein
(3) R 10 , R 11 , R 12 , R 13 , and R 14 , together with bonds "a" and "b" form any of a variety of lactam-containing moieties known in the art to have antimicrobial activity; and
(4) the linking moiety includes (for example) carbamate, dithiocarbamate, urea, thiourea, isouronium, isothiouronium, guanidine, carbonate, trithiocarbonate, reversed carbamate, xanthate, reversed isouronium, reversed dithiocarbamate, reversed isothiouronium, amine, imine, ammonium, heteroarylium, ether, thioether, phosphono, phosphoramide, phosphate, sulfonamide, ester, thioester, amide, and hydrazide groups.
wherein
(1) A 1 , A 2 , A 3 , R 1 , R 4 and R 6 generally form any of a variety of quinolone, naphthyridine or related cyclic moieties known in the art to have antimicrobial activity; and
(2) R 1 or R 3 contain a linking moiety, linking the quinolone moiety to a lactam-containing moiety having the formula:
wherein
(3) R 10 , R 11 , R 12 , R 13 , and R 14 , together with bonds "a" and "b" form any of a variety of lactam-containing moieties known in the art to have antimicrobial activity; and
(4) the linking moiety includes (for example) carbamate, dithiocarbamate, urea, thiourea, isouronium, isothiouronium, guanidine, carbonate, trithiocarbonate, reversed carbamate, xanthate, reversed isouronium, reversed dithiocarbamate, reversed isothiouronium, amine, imine, ammonium, heteroarylium, ether, thioether, phosphono, phosphoramide, phosphate, sulfonamide, ester, thioester, amide, and hydrazide groups.
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