发明授权
EP1000029B1 (+)-NORCISAPRIDE USEFUL FOR 5-HT3 AND 5-HT4 MEDIATED DISORDERS
失效
（+） - 诺西沙必利适合5-HT3和5-HT4相关性疾病
- 专利标题： (+)-NORCISAPRIDE USEFUL FOR 5-HT3 AND 5-HT4 MEDIATED DISORDERS
- 专利标题（中）： （+） - 诺西沙必利适合5-HT3和5-HT4相关性疾病
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申请号： EP98940159.1申请日： 1998-07-07
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公开(公告)号： EP1000029B1公开(公告)日： 2003-10-01
- 发明人: HEYKANTS, Jozef, Jan, Pieter , MEGENS, Antonius, Adrianus, Hendrikus, Petrus , MEULDERMANS, Willem, Emiel, Gustaaf , SCHUURKES, Joannes, Adrianus, Jacobus
- 申请人： JANSSEN PHARMACEUTICA N.V.
- 申请人地址： Turnhoutsebaan 30 2340 Beerse BE
- 专利权人： JANSSEN PHARMACEUTICA N.V.
- 当前专利权人： JANSSEN PHARMACEUTICA N.V.
- 当前专利权人地址： Turnhoutsebaan 30 2340 Beerse BE
- 优先权： EP97202161 19970711; EP98200661 19980304
- 国际公布： WO99002496 19990121
- 主分类号： C07D211/58
- IPC分类号： C07D211/58 ; A61K31/445
摘要：
The present invention concerns (+)-norcisapride of formula (I) and compounds (V), and its pharmaceutically acceptable acid additions salts, a process for preparing said compound, and its use for the manufacture of a medicament for treating gastro-intestinal disorders while avoiding central nervous system effects. Also provided are method of treating gastro-intestinal disorders. Compounds of formula (V) wherein the piperidine ring has the absolute configuration (3S, 4R) and PG is methyloxycarbonyl, ethyloxycarbonyl, tert-butyloxycarbonyl or phenylmethyl.
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