发明公开
- 专利标题： LYXOFURANOSYL BENZIMIDAZOLES AS ANTIVIRAL AGENTS
- 专利标题（中）： LYX非呋喃酰基苯并咪唑作为抗病毒药物
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申请号： EP98937254.5申请日： 1998-07-29
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公开(公告)号： EP1000080A1公开(公告)日： 2000-05-17
- 发明人: TOWNSEND, Leroy, B. , DRACH, John, C. , BIRON, Karen,K. , BOYD, Frank,L. Jr.
- 申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , GLAXO GROUP LIMITED
- 申请人地址： Technology Management Office,Wolverine Towers,Room 2071,3003 South State Street Ann Arbor,Michigan 48109-1280 US
- 专利权人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN,GLAXO GROUP LIMITED
- 当前专利权人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN,GLAXO GROUP LIMITED
- 当前专利权人地址： Technology Management Office,Wolverine Towers,Room 2071,3003 South State Street Ann Arbor,Michigan 48109-1280 US
- 代理机构： Sexton, Jane Helen
- 优先权： US54286P 19970730; US92929P 19980715
- 国际公布： WO9906424 19990211
- 主分类号： C07H19/052
- IPC分类号： C07H19/052 ; A61K31/70
摘要：
The present invention pertains to D- and L-lyxofuranosyl benzimidazole compounds. In one embodiment, the present invention pertains to D- and L-lyxofuranosyl benzimidazole compounds selected from the group consisting of compounds having a formula selected from the following: (beta-D), (beta-L), (alpha-L) and (alpha-D) wherein R?2, R4, R5, R6, and R7¿ are independently the same or different and independently selected from the group consisting of: -H, -F, -Cl, -Br, -I, -NO¿2?, -N(R?8)¿2, -OR?8, -SR12¿, and -CF¿3?, wherein R?8¿ is independently -H or an alkyl group having 1-6 carbon atoms and wherein R12 is independently -H or a hydrocarbyl group having 1-10 carbon atoms; and R?9, R10 and R11¿ are independently the same or different and are H or a hydroxyl protecting group; anomeric and optical isomers thereof; and pharmaceutically acceptable salts and prodrug derivatives thereof. The present invention also pertains to antiviral compositions using these compounds, methods of treating a viral infection using these compounds, and the use of these compounds in the preparation of a medicament for use in the treatment of a viral infection.
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