发明公开
EP1007049A1 NEW PHARMACEUTICAL COMPOSITIONS OF MELOXICAM WITH IMPROVED SOLUBILITY AND BIOAVAILABILITY
审中-公开
具有改善的溶解性和生物利用度MELOXICAMHALTIGE新药
- 专利标题: NEW PHARMACEUTICAL COMPOSITIONS OF MELOXICAM WITH IMPROVED SOLUBILITY AND BIOAVAILABILITY
- 专利标题(中): 具有改善的溶解性和生物利用度MELOXICAMHALTIGE新药
-
申请号: EP98947467.1申请日: 1998-08-27
-
公开(公告)号: EP1007049A1公开(公告)日: 2000-06-14
- 发明人: STRUENGMANN, Andreas , FREUDENSPRUNG, Brigitte , KLOKKERS, Karin
- 申请人: Hexal AG
- 申请人地址: Industriestrasse 25 83607 Holzkirchen DE
- 专利权人: Hexal AG
- 当前专利权人: Hexal AG
- 当前专利权人地址: Industriestrasse 25 83607 Holzkirchen DE
- 代理机构: Boeters, Hans Dietrich, Dr.
- 优先权: EP97114816 19970827
- 国际公布: WO9909988 19990304
- 主分类号: A61K31/54
- IPC分类号: A61K31/54 ; A61K47/26 ; A61K47/38 ; A61K47/40
摘要:
Pharmaceutical compositions containing enolic carboxamide type antiinflammatory agent meloxicam that exhibit improved wettability, aqueous solubility, dissolution behaviour over a broad range of pH, and that are prepared by crystal structure modification of the drug through dry or wet mechanical homogenization with two further components - one of them is selected from a group of oligo - and dissolution improving, or alkalizing agent. The application of the formulations according to the present invention results in an improved biovailability and effectiveness of meloxicam.
信息查询