发明授权
EP1017421B1 Use of adenoviral vectors expressing VEGF or PDGF FOR HEALING TISSUE DEFECTS AND INDUCING HYPERVASCULARITY IN MAMMALIAN TISSUE
失效
使用表达PDGF或VEGF，愈合和组织缺损腺病毒载体，以诱导HYPERVASKULITÄT在哺乳动物组织中
- 专利标题： Use of adenoviral vectors expressing VEGF or PDGF FOR HEALING TISSUE DEFECTS AND INDUCING HYPERVASCULARITY IN MAMMALIAN TISSUE
- 专利标题（中）： 使用表达PDGF或VEGF，愈合和组织缺损腺病毒载体，以诱导HYPERVASKULITÄT在哺乳动物组织中
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申请号： EP98909027.9申请日： 1998-03-06
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公开(公告)号： EP1017421B1公开(公告)日： 2005-05-25
- 发明人: HERLYN, Meenhard , NESBIT, Mark , SATYAMOORTHY, Kapaettu
- 申请人： THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY
- 申请人地址： 3601 Spruce Street Philadelpia, PA 19104-4268 US
- 专利权人： THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY
- 当前专利权人： THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY
- 当前专利权人地址： 3601 Spruce Street Philadelpia, PA 19104-4268 US
- 代理机构： Hale, Stephen Geoffrey
- 优先权： US40042P 19970307
- 国际公布： WO1998039035 19980911
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; C12N5/16 ; C12N5/06 ; C12N15/86 ; C12N15/11 ; A61K38/19 ; A61P17/02
摘要：
A method for repairing defects and inducing vascularization in mammalian tissue, preferably skin, involves administering to the tissue a recombinant replication defective virus, preferably adenovirus, carrying a selected growth factor gene, preferably VEGF or PDGF, under operative control of regulatory sequences which direct the expression of the growth factor(s). Also provided is a method for infecting a tissue to be transplanted with such recombinant adenoviruses prior to transplantation and, as a composition, an infected culture of human tissue to be transplanted which is infused with a selected growth factor prior to transplantation. Screening methods for the treatment of angiogenic disorders, e.g., hemangiomas and cancers, also employ an animal model on which is engrafted a full thickness human tissue infused with a growth factor.
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