发明授权
EP1019524B1 METHOD FOR IDENTIFYING INDUCERS AND INHIBITORS OF PROGRAMMED CELL DEATH
失效
一种用于识别电感和程序性细胞死亡的抑制剂
- 专利标题： METHOD FOR IDENTIFYING INDUCERS AND INHIBITORS OF PROGRAMMED CELL DEATH
- 专利标题（中）： 一种用于识别电感和程序性细胞死亡的抑制剂
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申请号： EP98903847.6申请日： 1998-01-30
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公开(公告)号： EP1019524B1公开(公告)日： 2004-09-29
- 发明人: ROIZMAN, Bernard , BIN, He
- 申请人： ARCH DEVELOPMENT CORPORATION
- 申请人地址： 1101 East 58th Street Chicago, IL 60637 US
- 专利权人： ARCH DEVELOPMENT CORPORATION
- 当前专利权人： ARCH DEVELOPMENT CORPORATION
- 当前专利权人地址： 1101 East 58th Street Chicago, IL 60637 US
- 代理机构： Forstmeyer, Dietmar, Dr. rer. nat., Dipl.-Chem.
- 优先权： US36997P 19970131; US795470 19970204
- 国际公布： WO1998033933 19980806
- 主分类号： C12Q1/00
- IPC分类号： C12Q1/00
摘要：
Methods for identifying inducers and inhibitors of programmed cell death in a cell-free system are described. The methods exploit the finding that programmed cell death is accompanied by shutdown of cellular protein synthesis and by phosphorylation of eIF-2 alpha and that the dephosphorylation of eIF-2 alpha prevents the shutdown of protein synthesis.
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