发明公开
- 专利标题： COBALT SCHIFF BASE COMPOUNDS
- 专利标题（中）： 席夫碱钴化合物
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申请号： EP96944811申请日： 1996-12-12
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公开(公告)号： EP1021176A4公开(公告)日： 2001-04-11
- 发明人: MEADE THOMAS J , TAKEUCHI TOSHIHIKO , GRAY HARRY B , SIMON MELVIN , LOUIE ANGELIQUE Y
- 申请人： CALIFORNIA INST OF TECHN
- 专利权人： CALIFORNIA INST OF TECHN
- 当前专利权人： CALIFORNIA INST OF TECHN
- 优先权： US57076195 1995-12-12
- 主分类号： C12N9/99
- IPC分类号： C12N9/99 ; A61K31/295 ; A61P31/04 ; A61P31/12 ; C07C251/12 ; C07F15/06 ; C07H21/00 ; C07K2/00 ; A61K31/045 ; A61K31/13 ; A61K31/19 ; A61K31/70 ; A61K38/02 ; C07H23/00 ; C12N9/74
摘要：
The invention relates to cobalt compounds in which divalent or trivalent cobalt is complexed with water soluble tetradentate Schiff's bases. The tetradentate Schiff's bases preferably contain two nitrogen atoms and two oxygen atoms as coordinating atoms. The compounds can contain polypeptide or nucleic acid targeting moities and can be used to inhibit enzymes such as thrombin and to inhibit zinc finger proteins.
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