发明公开
- 专利标题: PHARMACOLOGICALLY ACTIVE COMPOUNDS AND USE
- 专利标题(中): 吩噻衍生物对抑制单胺氧化酶
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申请号: EP97951761.2申请日: 1997-08-19
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公开(公告)号: EP1021434A2公开(公告)日: 2000-07-26
- 发明人: WHITE, Helen, Lyng , HARFENIST, Morton , BOROS, Eric , HEYER, Dennis
- 申请人: Krenitsky Pharmaceutical Inc
- 申请人地址: Four University Place4611 University Drive Durham, NC 27707 US
- 专利权人: Krenitsky Pharmaceutical Inc
- 当前专利权人: Krenitsky Pharmaceutical Inc
- 当前专利权人地址: Four University Place4611 University Drive Durham, NC 27707 US
- 代理机构: Bankes, Stephen Charles Digby
- 优先权: US25956P 19960911
- 国际公布: WO9812190 19980326
- 主分类号: C07D327/00
- IPC分类号: C07D327/00
摘要:
Compounds of formula (I) wherein n is 0, 1 or 2; R1 is a branched or straight chain C1-5 alkyl or C3-6 cycloalkyl optionally substituted with hydroxyl, or one or more halogens, especially fluorine; and X?1, X2, X3, X4, and X5¿ are either all hydrogens or one or two of X?1, X2, X3, X4, and X5¿ are halogen and the remainder are hydrogens. These compounds inhibit monoamine oxidase-A and are useful in the treatment of disorders such as depression.
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