发明公开
- 专利标题: Opioid formulations for treating pain
- 专利标题(中): 用于治疗疼痛的阿片制剂
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申请号: EP00107670.2申请日: 1994-11-22
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公开(公告)号: EP1023896A9公开(公告)日: 2007-05-23
- 发明人: Sackler, Richard , Goldenheim, Paul , Kaiko, Robert
- 申请人: Euro-Celtique S.A.
- 申请人地址: 122, Boulevard de la Pétrusse 2330 Luxembourg LU
- 专利权人: Euro-Celtique S.A.
- 当前专利权人: Euro-Celtique S.A.
- 当前专利权人地址: 122, Boulevard de la Pétrusse 2330 Luxembourg LU
- 代理机构: Maiwald Patentanwalts GmbH
- 优先权: US156468 19931123
- 主分类号: A61K9/54
- IPC分类号: A61K9/54 ; A61K31/137
摘要:
An oral sustained release opioid formulation comprises a plurality of substrates comprising a unit dose of an opioid analgesic which is tramadol or a salt thereof, each of said substrates comprising an inert bead coated with tramadol or a salt thereof and overcoated with a sustained release coating comprising a retardant material such that said unit dose provides therapeutically effective blood levels of said opioid analgesic for about 24 hours, said formulation providing an initially rapid rate of rise in the plasma concentration of said opioid characterised by providing an absorption half-life from 1 to 8 hours in the fasted state.
公开/授权文献
- EP1023896B1 Opioid formulations for treating pain 公开/授权日:2007-01-03
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