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EP1023896A9 Opioid formulations for treating pain 失效
用于治疗疼痛的阿片制剂

Opioid formulations for treating pain
摘要:
An oral sustained release opioid formulation comprises a plurality of substrates comprising a unit dose of an opioid analgesic which is tramadol or a salt thereof, each of said substrates comprising an inert bead coated with tramadol or a salt thereof and overcoated with a sustained release coating comprising a retardant material such that said unit dose provides therapeutically effective blood levels of said opioid analgesic for about 24 hours, said formulation providing an initially rapid rate of rise in the plasma concentration of said opioid characterised by providing an absorption half-life from 1 to 8 hours in the fasted state.
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