发明授权
EP1033978B1 D2-AGONIST ENTHALTENDES TRANSDERMALES THERAPEUTISCHES SYSTEM ZUR BEHANDLUNG DES PARKINSON-SYNDROMS UND VERFAHREN ZU SEINER HERSTELLUNG
有权
D 2激动剂CONTAINING透皮治疗系统用于帕金森氏综合征和方法的用于制造治疗
- 专利标题： D2-AGONIST ENTHALTENDES TRANSDERMALES THERAPEUTISCHES SYSTEM ZUR BEHANDLUNG DES PARKINSON-SYNDROMS UND VERFAHREN ZU SEINER HERSTELLUNG
- 专利标题（英）： Transdermal therapeutic system which contains a d2 agonist and which is provided for treating parkinsonism, and a method for the production thereof
- 专利标题（中）： D 2激动剂CONTAINING透皮治疗系统用于帕金森氏综合征和方法的用于制造治疗
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申请号： EP99910359.1申请日： 1999-03-18
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公开(公告)号： EP1033978B1公开(公告)日： 2001-12-19
- 发明人: MÜLLER, Walter , PECK, James, V.
- 申请人： LTS Lohmann Therapie-Systeme AG , Discovery Therapeutics, Inc.
- 申请人地址： Lohmannstrasse 2 56626 Andernach DE
- 专利权人： LTS Lohmann Therapie-Systeme AG,Discovery Therapeutics, Inc.
- 当前专利权人： LTS Lohmann Therapie-Systeme AG,Discovery Therapeutics, Inc.
- 当前专利权人地址： Lohmannstrasse 2 56626 Andernach DE
- 代理机构： Flaccus, Rolf-Dieter, Dr.
- 优先权： DE19814084 19980330
- 国际公布： WO9949852 19991007
- 主分类号： A61K9/70
- IPC分类号： A61K9/70
摘要：
The invention relates to a transdermal therapeutic system comprising a back layer which is inert with respect to the constituents of the matrix, a self-adhesive matrix layer containing an effective quantity of (-)-5,6,7,8,-tetrahydro-6-[propyl[2-(2-thienyl)-ethyl]amino]-1-naphthol, and a protective film which is to be removed before use. The invention is characterized by a matrix based on a non-aqueous polymer adhesive system, said system being based on acrylate or silicon, with a solubility for (-)-5,6,7,8,-tetrahydro-6-[propyl[2-(2-thienyl)-ethyl]amino]-1-naphthol of >/=5 % g/g. Said matrix is essentially free of inorganic silicate particles.
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