发明公开
EP1035842A1 IMPROVED HMG CoA REDUCTASE INHIBITOR EXTENDED RELEASE FORMULATION
有权
改进的HMG CoA还原酶抑制剂配方缓释
- 专利标题： IMPROVED HMG CoA REDUCTASE INHIBITOR EXTENDED RELEASE FORMULATION
- 专利标题（中）： 改进的HMG CoA还原酶抑制剂配方缓释
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申请号： EP98960752.8申请日： 1998-12-04
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公开(公告)号： EP1035842A1公开(公告)日： 2000-09-20
- 发明人: CHEN, Chih-Ming , CHOU, Joseph , WONG, David
- 申请人： ANDRX PHARMACEUTICALS, INC.
- 申请人地址： Suite 201,4001 S.W. 47th Avenue Fort Lauderdale, FL 33314 US
- 专利权人： ANDRX PHARMACEUTICALS, INC.
- 当前专利权人： ANDRX PHARMACEUTICALS, INC.
- 当前专利权人地址： Suite 201,4001 S.W. 47th Avenue Fort Lauderdale, FL 33314 US
- 代理机构： Gervasi, Gemma, Dr.
- 优先权： US989253 19971212
- 国际公布： WO9930692 19990624
- 主分类号： A61K9/36
- IPC分类号： A61K9/36
摘要：
A controlled release dosage formulation is described which is based on a combination of: (a) a compressed tablet core which contains an alkyl ester of a hydroxy substituted naphthalene derivative, a pharmaceutically acceptable, water swellable polymer and an osmotic agent; and (b) an outer coating layer which completely covers the osmotic core and comprises a pH sensitive coating agent and a water insoluble polymer.
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