- 专利标题： INTEGRIN RECEPTOR ANTAGONISTS
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申请号： EP98963915.8申请日： 1998-12-14
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公开(公告)号： EP1040111B1公开(公告)日： 2005-06-22
- 发明人: DUGGAN, Mark, E. , MEISSNER, Robert, S. , HUTCHINSON, John, H. , HALCZENKO, Wasyl , ASKEW, Ben, C. , COLEMAN, Paul, J. , PATANE, Michael, A. , WANG, Jiabing , PERKINS, James J.
- 申请人： MERCK & CO., INC.
- 申请人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065 US
- 专利权人： MERCK & CO., INC.
- 当前专利权人： MERCK & CO., INC.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065 US
- 代理机构： Horgan, James Michael Frederic
- 优先权： US69910P 19971217; US79197P 19980324; US79944P 19980330; US80397P 19980402; US83251P 19980427; GB9810182 19980513; GB9810882 19980520; GB9810892 19980520; GB9811283 19980526; GB9812686 19980612; US92588P 19980713; US92624P 19980713; US99948P 19980911; GB9822331 19981013; GB9822701 19981016
- 国际公布： WO1999031099 19990624
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; C07D401/06 ; C07D401/14 ; C07D519/00 ; A61K31/415 ; A61K31/44
摘要：
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors αvβ3, αvβ5 and/or αvβ6 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, wound healing, viral disease, and tumor growth and metastasis.
公开/授权文献
- EP1040111A1 INTEGRIN RECEPTOR ANTAGONISTS 公开/授权日：2000-10-04
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