The invention concerns a sprayer (12) actuating device comprising a support (22) whereon the sprayer (12) is supported and a member (24) actuating the sprayer knob (18) mobile axially relative to the support by the action of the control means (34, 36, 43, 46, 47, 58) between a position driving in the knob (18) and a position releasing it, the control means (34, 36, 43, 47 58) comprising elastic means (36) for urging the actuating member in depressing position and means capable of disengaging (58) the lock of the actuating member into releasing position. The control means comprise a rotatable handle (43) manually actuated by a user and associated to a cam (43) moving the actuating member (24) from the depressing position to the releasing position.