发明公开
EP1054012A4 PURINE DERIVATIVES AND ADENOSINE A2 RECEPTOR ANTAGONISTS SERVING AS PREVENTIVES/REMEDIES FOR DIABETES
有权
嘌呤衍生物和腺苷A2受体的拮抗剂，它们的提供或治愈糖尿病的
- 专利标题： PURINE DERIVATIVES AND ADENOSINE A2 RECEPTOR ANTAGONISTS SERVING AS PREVENTIVES/REMEDIES FOR DIABETES
- 专利标题（中）： 嘌呤衍生物和腺苷A2受体的拮抗剂，它们的提供或治愈糖尿病的
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申请号： EP98961528申请日： 1998-12-24
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公开(公告)号： EP1054012A4公开(公告)日： 2001-12-12
- 发明人: ASANO OSAMU , HARADA HITOSHI , HOSHINO YORIHISA , YOSHIKAWA SEIJI , INOUE TAKASHI , HORIZOE TATSUO , YASUDA NOBUYUKI , NAGATA KAYA , NAGAOKA JUNSAKU , MURAKAMI MANABU , KOBAYASHI SEIICHI
- 申请人： EISAI CO LTD
- 专利权人： EISAI CO LTD
- 当前专利权人： EISAI CO LTD
- 优先权： JP52698 1998-01-05
- 主分类号： A61K31/52
- IPC分类号： A61K31/52 ; A61P3/10 ; C07D473/00 ; C07D473/30 ; C07D473/34 ; A61K31/505 ; A61K45/00 ; C07D473/04 ; C07D473/40 ; C07D487/04 ; C07D487/14 ; A61K31/645
摘要：
Preventives/remedies of a novel type for diabetes and complications thereof based on the adenosine A2 receptor antagonism. Purine derivatives represented by general formula (I), pharmacologically acceptable salts thereof or hydrates of the same have adenosine A2 receptor antagonism and are useful in preventing and treating diabetes and its complications. Moreover, adenosine A2 receptor antagonists being different from the above compounds in structure, for example KW6002 are also useful in preventing and treating diabetes and its complications. In formula (I), W represents -CH2CH2-, -CH=CH- or -C≡C-; and R1 represents KW6002.
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