发明授权
- 专利标题： ANTI-VIRAL PYRIMIDINE DERIVATIVES
- 专利标题（中）： 抗坏血酸吡啶衍生物
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申请号： EP99905966.0申请日： 1999-02-12
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公开(公告)号： EP1056742B1公开(公告)日： 2003-07-23
- 发明人: CUSHING, Timothy D. , MELLON, Heather L. , JAEN, Juan C. , FLYGARE, John A. , MIAO, Shi-Chang , CHEN, Xiaoqi , POWERS, Jay P.
- 申请人： TULARIK, INC.
- 申请人地址： Two Corporate Drive South San Francisco, California 94080 US
- 专利权人： TULARIK, INC.
- 当前专利权人： TULARIK, INC.
- 当前专利权人地址： Two Corporate Drive South San Francisco, California 94080 US
- 代理机构： Sexton, Jane Helen
- 优先权： US75005P 19980217
- 国际公布： WO99041253 19990819
- 主分类号： C07D403/04
- IPC分类号： C07D403/04 ; C07D239/48 ; A61K31/505
摘要：
Compounds and compositions which are useful for the treatment of viral infections, particularly human Cytomegalovirus infection. The compounds include novel pyrimidine-based derivatives having formula (I) wherein X is a member selected from the group consisting of -NR?3R4, -OR3, -SR3¿, aryl, alkyl and arylalkyl; Y is a member selected from the group consisting of a covalent bond, -N(R6)-, -O-, -S-, -C(=O)- and alkylene; R?1 and R2¿ are members independently selected from the group consisting of hydrogen, alkyl, -O-alkyl, -S-alkyl, aryl, arylalkyl, -O-aryl, -S-aryl, -NO¿2?, -NR?7R8¿, -C(O)R9, -CO2R10, -C(O)NR?7R8, -N(R7)C(O)R9, -N(R7)CO¿2R?11, -N(R9)C(O)NR7R8¿, -S(O)¿mNR?7R8, -S(O)¿nR?9, -CN, halogen, and -N(R7)S(O)mR11.
公开/授权文献
- EP1056742A1 ANTI-VIRAL PYRIMIDINE DERIVATIVES 公开/授权日：2000-12-06
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