发明公开
- 专利标题： METHODS AND COMPOSITIONS FOR REGULATING CELL DEATH AND ENHANCING DISEASE RESISTANCE TO PLANT PATHOGENS
- 专利标题（中）： 方法和组合物调节细胞死亡，提高抗病植物中
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申请号： EP99911091.9申请日： 1999-03-03
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公开(公告)号： EP1058733A2公开(公告)日： 2000-12-13
- 发明人: JOHAL, Gurmukh, S. , BRIGGS, Steven, P. , GRAY, John , HU, Gongshe
- 申请人： PIONEER HI-BRED INTERNATIONAL, INC. , THE CURATORS OF THE UNIVERSITY OF MISSOURI
- 申请人地址： 800 Capital Square,400 Locust Street Des Moines, Iowa 50309 US
- 专利权人： PIONEER HI-BRED INTERNATIONAL, INC.,THE CURATORS OF THE UNIVERSITY OF MISSOURI
- 当前专利权人： PIONEER HI-BRED INTERNATIONAL, INC.,THE CURATORS OF THE UNIVERSITY OF MISSOURI
- 当前专利权人地址： 800 Capital Square,400 Locust Street Des Moines, Iowa 50309 US
- 代理机构： Goldin, Douglas Michael
- 优先权： US76754P 19980304
- 国际公布： WO9945125 19990910
- 主分类号： C12N15/60
- IPC分类号： C12N15/60 ; C12N15/82 ; A01H5/00 ; C12Q1/02
摘要：
Compositions and methods for enhancing disease resistance to a pathogen in a plant are provided. Methods of the invention comprise stably transforming a plant with an antisense nucleotide sequence for a gene encoding an enzyme in the C-5 porphyrin metabolic pathway and operably linking the antisense sequence to a pathogen-inducible promoter, such that invasion of a cell by a pathogen elicits a hypersensitive-like response that results in confinement of the pathogen to cells of initial contact. Transformed plants and seeds are provided. Nucleotide sequences encoding a wild-type maize urod gene useful in the present invention and the amino acid sequence for the protein encoded thereby are provided. These compositions are also useful for regulating cell death in specifically targeted tissues. A maize lesion mimic, dominant mutant phenotype, designated Les22, and the molecular basis for its manifestation are also provided.
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