发明公开
- 专利标题： CHEMICAL COMPOUNDS AND THEIR USE TO ELEVATE PYRUVATE DEHYDROGENASE ACTIVITY
- 专利标题（中）： 化合物和它们用于增丙酮酸脱氢酶活性
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申请号： EP99937876.3申请日： 1999-03-02
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公开(公告)号： EP1059927A1公开(公告)日： 2000-12-20
- 发明人: BUTLIN, Roger, John
- 申请人： AstraZeneca AB
- 申请人地址： 151 85 Södertälje SE
- 专利权人： AstraZeneca AB
- 当前专利权人： AstraZeneca AB
- 当前专利权人地址： 151 85 Södertälje SE
- 代理机构： Bill, Kevin
- 优先权： GB9804648 19980306
- 国际公布： WO9944618 19990910
- 主分类号： A61K31/63
- IPC分类号： A61K31/63
摘要：
The use of a compound of formula (I) wherein: ring C is phenyl or carbon-linked heteroaryl selected from pyridyl, pyrazinyl, pyrimidinyl and pyridazinyl; and wherein said phenyl or heteroaryl is substituted as defined herein; A-B is selected from NHCO, OCH2, SCH2, NHCH2, trans-vinylene, and ethynylene; R1 is linked to ring C at a carbon ortho to the position of A-B attachment and is defined herein; n is 1 or 2; R?2 and R3¿ are alkyl, haloalkyl or together from cycloalkyl or halocycloakyl as defined herein; in the manufacture of a medicament for use in the elevation of PDH activity in warm-blooded animals such as humans is described. Salts and esters of compounds of formula (I) are also described.
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