发明公开
- 专利标题： AMIDE DERIVATIVES AND NOCICEPTIN ANTAGONISTS
- 专利标题（中）： 酰胺衍生物，和NOCICEPTINANTAGONISTEN
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申请号： EP99909320.6申请日： 1999-03-23
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公开(公告)号： EP1072263A1公开(公告)日： 2001-01-31
- 发明人: SHINKAI, Hisashi, Ctl. Pharma. Rch. Inst. of Japan , ITO, Takao, Central Pharma. Rch. Inst. of Japan , YAMADA, Hideki, Ctl. Pharma. Rch. Inst. of Japan
- 申请人： Japan Tobacco Inc.
- 申请人地址： 2-1, Toranomon 2-chome, Minato-ku Tokyo 105-8422 JP
- 专利权人： Japan Tobacco Inc.
- 当前专利权人： Japan Tobacco Inc.
- 当前专利权人地址： 2-1, Toranomon 2-chome, Minato-ku Tokyo 105-8422 JP
- 代理机构： von Kreisler, Alek, Dipl.-Chem.
- 优先权： JP10002998 19980326
- 国际公布： WO9948492 19990930
- 主分类号： A61K31/165
- IPC分类号： A61K31/165 ; A61K31/415 ; A61K31/495 ; A61K31/47 ; C07D215/38 ; C07D215/42 ; C07D401/12 ; C07D405/12 ; C07D409/12 ; C07D235/28 ; C07D241/42 ; C07C235/42
摘要：
The present invention relates to a compound of the formula [1' ]
wherein R 2 is lower alkyl optionally substituted by hydroxy, amino and the like, ring B is phenyl, thienyl and the like, E is a single bond, -O-,-S- and the like, ring G is aryl, heterocyclic group and the like, R 5 is halogen atom, hydroxy, lower alkyl optionally substituted by halogen atom etc., and the like, t is 0 or an integer of 1 to 5, when t is an integer of 2 to 5, each R 5 may be the same or different, m is 0 or an integer of 1 to 8, and n is 0 or an integer of 1 to 4, and a nociceptin antagonist containing compound [1' ] as an active ingredient The compound [1' ] shows, due to nociceptin antagonistic action, analgesic effect against sharp pain such as postoperative pain and the like. The present invention also relates to the use of certain amide derivative inclusive of compound [1' ] as a nociceptin antagonist or analgesic.
wherein R 2 is lower alkyl optionally substituted by hydroxy, amino and the like, ring B is phenyl, thienyl and the like, E is a single bond, -O-,-S- and the like, ring G is aryl, heterocyclic group and the like, R 5 is halogen atom, hydroxy, lower alkyl optionally substituted by halogen atom etc., and the like, t is 0 or an integer of 1 to 5, when t is an integer of 2 to 5, each R 5 may be the same or different, m is 0 or an integer of 1 to 8, and n is 0 or an integer of 1 to 4, and a nociceptin antagonist containing compound [1' ] as an active ingredient The compound [1' ] shows, due to nociceptin antagonistic action, analgesic effect against sharp pain such as postoperative pain and the like. The present invention also relates to the use of certain amide derivative inclusive of compound [1' ] as a nociceptin antagonist or analgesic.
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